[1] LU J, ROHANI S. Polymorphism and crystallization of active pharmaceutical ingredients (APIs) . Curr Med Chem, 2009, 16(7)884-905.

[2] BERGSTROM P O, FISCHER A, KLOO L, et al. Crystal structure and physical properties of two polymorphs of ropivacaine HCl . J Pharm Sci, 2006, 95(3)680-688.

[3] DU G H, LV Y. Optimal drug crystal form of solid pharmaceutic chemicals . Chin Pharm J (中国药学杂志), 2010, 45(1)5-10.

[4] ZHANG W G, LIU C X. Bioavailability research summary of polymorphic drugs . Tianjin Pharm (天津药学), 2007, 19(2)59-61.

[5] CHEN G M. Polymorphic drugs of chloramphenicol palmitate . Pharm Bull (药学通报), 1982, 17(2)29.

[6] JIN G Z, LIN Y N, WANG J, et al. Polymorphism of indolacin (2):Determination of solubility and dissolution rates of various polymophic forms . J Shenyang Pharm Univ (沈阳药科大学学报), 1995, 12(1)1-4, 45.

[7] BASAVOJU S, BOSTROM D, VELAGA S P. Indomethacin-saccharin cocrystalDesign, synthesis and preliminary pharmaceutical characterization . Pharm Res, 2008, 25(3)530-541.

[8] WU X H. Relationship between the rifamycins polymorphic forms and the drug content in plasma (urine) . J Wenzhou Med Coll (温州医学院学报), 2001, 31(4)225-226.

[9] YU X Y, CHEN Q X, BAI X Y, et al. Absorption dynamic characteristics of clopidogrel bisulfate polymorphs in rat . Acta Pharm Sin (药学学报), 2011, 46(10)1268-1272.

[10] SUN J L, CHEN Q X, TIAN S, et al. Absorption of risperidone polymorphs administrated orally in rats . Chin Pharm J (中国药学杂志), 2011, 46(24)1919-1922.

[11] HE G R, LV Y, DU G H. The technology of substances crystal problem and its activity evaluation in drug discovery . Pharmaceutical development frontier forum (药学发展前沿论坛), November 13-16, Taiyuan, Shan-Xi, 2008:112-113.

[12] NOUREDDINE N, ZERROUK N, NICOLIS I, et al. Characterization of the absorption of theophylline from immediate- and controlled-release dosage forms with a numerical approach using caco-2 the in vitro dissolution-permeation process using cells . Drug Dev Ind Pharm, 2005, 31(4-5)397-404.

[13] COYUCO J C, LIU Y, TAN B J, et al. Functionalized carbon nanomaterialsExploring the interactions with Caco-2 cells for potential oral drug delivery . Int J Nanomed, 2011, 62253-2263.

[14] ARTURSSON P, BORCHARDT R T. Intestinal drug absorption and metabolism in cell culturesCaco-2 and beyond . Pharm Res, 1997, 4(12)1655-1658.

[15] KOBAYASHI S, NAGAI T, KONISHI Y, et al. Transport mechanisms of flavanone aglycones across Caco-2 cell monolayers and artificial PAMPA membranes . J Pharm Pharmacol, 2012, 64(1)52-60.

[16] YAMASHITA S, TANAKA Y, ENDOH Y, et al. Analysis of drug permeation across Caco-2 monolayerImplication for predicting in vivo drug absorption . Pharm Res, 1997, 14(4)486-491.

[17] PRESS B. Optimization of the Caco-2 permeability assay to screen drug compounds for intestinal absorption and efflux . Methods Mol Biol, 2011, 763139-154.

[18] LEONI B D, NATOLI M, NARDELLA M, et al. Differentiation of Caco-2 cells requires both transcriptional and post-translational down-regulation of Myc . Differentiation, 2012, 83(3)116-127.

[19] LI J, VOLPE D A, WANG Y, et al. Use of transporter knockdown Caco-2 cells to investigate the in vitro efflux of statin drugs . Drug Metab Dispos, 2011, 39(7)1196-1202.

[20] IRAINE J D, TAKAHASHI L, LOCKHART K, et al. MDCK (Madin-Darby canine kidney) cellsA tool for membrane permeability screening . J Pharm Sci, 1999, 88(1)28-33.

[21] PASTAN I, GOTTESMAN M M, UEDA K, et al. A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells . Proc Natl Acad Sci USA, 1988, 5(12)4486-4490.

[22] LARSON B, BANKS P, SHERMAN H, et al. Automation of cell-based drug absorption assays in 96-well format using permeable support systems . J Lab Autom, 2012, 17(3):222-232.

[23] ROZEHNAL V, NAKAI D, HOEPNER U, et al. Human small intestinal and colonic tissue mounted in the using chamber as a tool for characterizing the intestinal absorption of drugs . Eur J Pharm Sci, 2012, 46(5):367-373.

[24] FORTUNA A, ALVES G, FALCAO A, et al. Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the ussing chamber technique . Epilepsia, 2012, 3(3)529-538.

[25] PAN D C, SUN T T, SUN Y B, et al. Rat intestinal absorption trait of danshensu and protocatechuic aldehyde in Salviae Miltiorrhizae Radix et Rhizoma extract by single pass perfusion . Chin Tradit Herb Durgs (中草药), 2011, 42(5)944-950.

[26] SUN M, ZHAI X, XUE K, et al. Intestinal absorption and intestinal lymphatic transport of sirolimus from self-microemulsifying drug delivery systems assessed using the single-pass intestinal perfusion (SPIP) technique and a chylomicron flow blocking approachLinear correlation with oral bioavailabilities in rats . Eur J Pharm Sci, 2011, 43(3)132-140.

[27] TAN W, WANG B L, HU J P, et al. Establishment of liquid chromatography/ mass spectrometry for determination of bicyclol in rat single-pass intestinal perfusion . Biomed Chromatogr, 2009, 23(10)1059-1063.

[28] DU G H. Fill the stomachChina，CN201870770U. 2011-06-22.

QIANG G F, LV Y, DU G H. The present situation and development direction of the research for polymorphic drugs in China . Chin J New Drugs (中国新药杂志), 2009, 18(13)1196-1200.